This document describes how to install a Postfix mail server that is based on virtual users and domains, i.e. users and domains that are in a MySQL database. I will also demonstrate the installation and configuration of Courier (Courier-POP3, Courier-IMAP), so that Courier can authenticate against the same MySQL database Postfix uses.

http://www.howtoforge.com/virtual_users_and_domains_with_postfix_debian_etch