Short bio: Computer Scientist, FOSS supporter (read more)
Tux Machines (TM)-specific
That's right folks, another ten best! But this time I'll wager you're not familiar with any of them, or at best one or two. The free/open source software world is vast and full of excellent applications for all occasions. An interesting trend is the growth of large distributed projects such as OpenTox and AMEE. FOSS presents a natural platform for building large distributed projects because of the low barrier to entry-- open code, open standards, and freely-available robust, high-quality high-performance software.
And now I shall cease nattering, and invite you to enjoy the following best unknown open source software projects.
OpenTox Replaces Animal Testing
The OpenTox project aims to "develop an interoperable predictive toxicology framework which may be used as an enabling platform for the creation of predictive toxicology applications." In other words, using computer modeling instead of animal testing for chemical toxicity testing. Animal testing is cruel, and it is limited: expensive, slow, and not always an accurate predictor of how chemicals will affect humans.