Short bio: Computer Scientist, FOSS supporter (read more)
Tux Machines (TM)-specific
Having looked at the two main editions of Gnome x86 and KDE x64 I've come to the conclusion, that the best way to use Sabayon 6 on the desktop is... to log into Fluxbox. When talking about the installer I briefly mentioned that it launches in a Fluxbox environment if you choose install directly from the boot menu, which it falls back into if things go wrong, and believe me they do.
Both editions have it as a great light weight alternative. The menu is customized enough to allow access to several applications including Konsole, no dead entries. It's a good start and if you want to use it full time you can add the rest later.
I found going into Fluxbox on the KDE spin gave me the responsiveness that I had been looking for, and you can still have all your preferred applications just a click or a run command away.